That's finally set to be resolved with Nova Lake later this year, which will support AVX10 (the new iteration of AVX512) across both core types. Better very late than never.
E cores didn't just ruin P cores, it ruined AVX-512 altogether. We were getting so close to near-universal AVX-512 support; enough to bother actually writing AVX-512 versions of things. Then, Intel killed it.
I love the AVX512 support in Zen 5 but the lack of Valgrind support for many of the AVX512 instructions frustrates me almost daily. I have to maintain a separate environment for compiling and testing because of it.
There was someone at Intel working on AVX512 support in Valgrind. She is/was based in St Petersburg. Intel shuttered their Russian operations when Putin invaded Ukraine and that project stalled.
If anyone has the time and knowledge to help with AVX512 support then it would be most welcome. Fair warning, even with the initial work already done this is still a huge project.
